The Benefits of Niacinamide for Skin: What Science Says
Pronounced: Nye-uh-sin-uh-mide
Niacinamide has earned its place as one of skincare’s most well-rounded and research-backed ingredients. Whether you're struggling with acne, uneven tone, sensitivity, or early signs of aging, niacinamide might be the multitasker your routine needs.
🔬 What is Niacinamide?
Niacinamide — also known as nicotinamide — is a water-soluble form of Vitamin B3. It plays a key role in cellular energy production and DNA repair. In skincare, it's prized for its ability to support the skin barrier, reduce inflammation, and regulate oil production.
🧪 Scientifically Proven Benefits
1. Strengthens the Skin Barrier
Niacinamide stimulates the production of ceramides, lipids that hold skin cells together and prevent moisture loss. This leads to better hydration and improved skin resilience.
-
Study: A 2000 double-blind clinical trial showed that topical niacinamide improved skin barrier function, hydration, and reduced transepidermal water loss in patients with atopic dermatitis.
→ Source: Journal of Dermatology
2. Reduces Hyperpigmentation
Niacinamide inhibits the transfer of melanin (pigment) from melanocytes to skin cells, helping to fade dark spots and improve overall skin tone.
-
Study: A 4-week study showed that 5% niacinamide significantly reduced hyperpigmentation and improved skin brightness.
→ Source: British Journal of Dermatology
3. Regulates Oil Production
Niacinamide helps control sebum (oil) production, which is especially helpful for oily or acne-prone skin.
-
Study: In a study with 100 participants, topical niacinamide reduced sebum excretion rates and improved the appearance of pores.
→ Source: International Journal of Cosmetic Science
4. Minimizes Pores
Niacinamide improves skin elasticity and barrier function, which helps reduce the appearance of enlarged pores over time.
5. Calms Inflammation
Niacinamide has anti-inflammatory properties that help soothe rosacea, acne, and eczema-prone skin.
-
Study: 4% niacinamide gel was found to be just as effective as 1% clindamycin gel in reducing acne lesions, without contributing to antibiotic resistance.
→ Source: International Journal of Dermatology
6. Anti-Aging Effects
By boosting collagen production and reducing oxidative stress, niacinamide can help reduce fine lines, improve elasticity, and enhance skin texture.
-
Study: A 12-week clinical trial on 50 women showed improved wrinkles, red blotchiness, and elasticity with 5% niacinamide use.
→ Source: Dermatologic Surgery Journal
✔️ Is Niacinamide Safe for All Skin Types?
Yes — it’s considered one of the most gentle and stable active ingredients in skincare. It’s suitable for dry, oily, sensitive, and combination skin types. Most people tolerate it well at concentrations of 2% to 10%.
However, very high concentrations (above 10%) may cause temporary flushing or tingling in sensitive individuals, especially if layered incorrectly with exfoliants.
🔄 Can Niacinamide Be Used with Other Actives?
Yes! Niacinamide pairs well with:
-
Retinol – to soothe irritation
-
Vitamin C – modern formulations show they are stable together
-
Hyaluronic Acid – for hydration
-
Peptides – for anti-aging synergy
Earlier concerns about niacinamide "canceling out" vitamin C have been debunked by recent formulation science.
→ Read more from Paula’s Choice Research Team
💡 Quick Recap: Why Dermatologists Love Niacinamide
| Benefit | Evidence Level | Notes |
|---|---|---|
| Skin barrier repair | ✅ Strong clinical support | Increases ceramides |
| Brightens skin | ✅ Strong clinical support | Fades pigmentation |
| Oil regulation | ✅ Moderate to strong | Helpful for acne |
| Anti-aging | ✅ Moderate support | Boosts collagen |
| Anti-inflammatory | ✅ Strong support | Great for sensitive skin |
| Safe for daily use | ✅ Yes | Even for rosacea |
🔗 References: